• Fat & Water Soluble Vitamin B1
• Dietary Supplement
• Gluten Free
• Non GMO LE Certified

Benfotiamine is the fat soluble form of vitamin B1 clinically tested to offer protection against advanced glycation end products, typically associated with blood glucose irregularities.

Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), supports healthy blood sugar metabolism and helps encourage the body’s tissues against advanced glycation end products and oxidative stress.

Benfotiamine is more bioavailable than water-soluble thiamine. It can also easily penetrate the inside of cells.

Benfotiamine with Thiamine Benefits

• Supports healthy blood sugar metabolism
• Promotes optimal thiamine levels important for supporting cardiovascular health
• Helps protect against advanced glycation end products
• Provides support against oxidative stress

Benfotiamine is a fat-soluble form of vitamin B1 (thiamine). Thiamine is needed for normal blood sugar metabolism via a non-oxygen-dependent metabolic pathway called the pentose phosphate pathway. The products of this pathway are needed for fatty acid, amino acid and nucleotide synthesis. Adequate levels of thiamine are especially critical to supporting healthy brain function, where cells rely on the pentose phosphate pathway for energy. Thiamine also helps encourage the body’s tissues against advanced glycation end products and oxidative stress, making maintaining optimal levels important for supporting cardiovascular and metabolic health.

Unfortunately, thiamine in most supplements (thiamine hydrochloride) is water-soluble, which makes it less available to the interior of the cell. As a fat-soluble form of thiamine, benfotiamine can easily penetrate the inside of cells. It has been shown to support thiamine levels faster and for longer than the water-soluble thiamine.

Thiamine is a cofactor for the pentose phosphate pathway enzyme, transketolase. In one study, benfotiamine effectively increased transketolase activity in cell cultures by 300%, compared with 20% for thiamine. This activation helps promote blood vessel health. Benfotiamine also supports a healthy inflammatory response in nuclear factor-kappa B (NF-kB) and encourages expression of nuclear factor erythroid 2-related factor 2 (Nrf2), which supports antioxidant activity in cells.

Benfotiamine has further been found to inhibit formation of neurofibrillary tangles and tau protein damage in brain tissue and support healthy lifespan in preclinical studies, as well as maintain endothelial cell function.

Overall, benfotiamine can support healthy glucose metabolism and promote healthy blood glucose levels in those already within normal range. Benfotiamine with Thiamine is a dietary supplement that can help maintain blood sugar levels in those already within normal range and support the health of the nerves, kidneys, eyes, blood vessels and heart.

In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage.1 Benfotiamine also blocks the activation of the transcription factor known as nuclear factor-kappa B (NF-kB), which is implicated in numerous inflammatory conditions.

Overall, benfotiamine can activate glucose metabolism and promote healthy blood glucose levels in those already within normal range. Benfotiamine also helps maintain healthy endothelial function. Benfotiamine with Thiamine is a low-cost dietary supplement that can help maintain blood sugar levels in those already within normal range and support the health of the nerves, kidneys, eyes, blood vessels, and heart.